Products

COMPOSITION
Azithromycin 500 mg tab
DRUG CLASS AND MECHANISM
Azithromycin is a semi-synthetic macrolide antibiotic chemically related to erythromycin and clarithromycin .It is effective against a wide variety of bacteria organisms, such as Hemophilus influenzae, Streptococcus pneumoniae, Mycoplasma pneumoniae, Staphylococcus aureus, and mycobacterium avium, and many others. It is unusual in that it stays in the body for quite a while, allowing for once a day dosing and for shorter treatment courses for most infections. Azithromycin, like all macrolide antibiotics, prevents bacteria from growing by interfering with their ability to make proteins. Due to the differences in the way proteins are made in bacteria and humans, the macrolide antibiotics do not interfere with humans' ability to make proteins.
PREPERATIONS: Tablet: 500 mg
PRESCRIBED FOR
Azithromycin is effective against susceptible bacteria causing infections of the middle ear, tonsillitis, throat infections, laryngitis, bronchitis, pneumonia and sinuses. It is also effective against certain sexually transmitted infectious diseases, such as gonococcal & nongonococcal urethritis and cervicitis
DOSING
Azithromycin should be taken at least one hour before or two hours after meals since it may bind to food and not be absorbed from the intestine. For most infections, azithromycin is taken once daily for a relatively short course of treatment (usually five days). The first dose is often a "double dose," twice as much as the remainder of the doses given. For acute bacterial sinusitis, azithromycin way be taken once daily for three days
DRUG INTERACTION
Unlike erythromycin and clarithromycin, azithromycin is generally considered free of interactions with most other medicines. It is recommended that azithromycin not be taken at the same time as aluminum- or magnesium- based antacids because antacids will bind the azithromycin and prevent it from being absorbed from the intestine.
PREGNANC
There are no adequate studies of azithromycin in pregnant women. However, studies in animals suggest no important effects on the fetus. Azithromycin therefore can be used in pregnancy if the physician feels that it is clearly necessary.
NURSING MOTHERS
It is not known if azithromycin is secreted in breast milk.
SIDE EFFECTS
Azithromycin is generally well tolerated. The most common side effects are diarrhea or loose stools, nausea, abdominal pain, and vomiting, each of which may occur in fewer than one in twenty persons who receive azithromycin. Rarer side effects include abnormal liver tests, allergic reactions, and nervousness

COMPOSITION
Each film-coated tablet contains 10 mg ebastine
PHARMACOLOGICAL CLASSIFICATION
Antihistamines
PHARMACOLOGICAL ACTION
Ebastine is a long-acting and selective H1-histamine receptor antagonist. After repeated administration, inhibition of peripheral receptors remain at a constant level. Ebastine is rapidly absorbed and undergoes extensive first pass metabolism following oral administration. Ebastine is almost totally converted to the pharmacologically active acid metabolite, carebastine. After a single 10 mg oral dose, peak plasma levels of carebastine occur at 2,6 to 4 hours and achieve levels of 80 to 100 ng/mL. The half-life of carebastine is between 15 and 19 hours with 66% of the medicine being excreted in the urine mainly as conjugated metabolites. Following repeated administration of 10 mg once daily, steady state is achieved in 3 to 5 days with peak plasma levels ranging from 130 to 160 ng/mL. In vitro studies with human liver microsomes show that ebastine is metabolised to carebastine predominantly via the CYP3A4 pathway. Concurrent administration of ebastine with ketoconazole or erythromycin (both CYP3A4 inhibitors) to healthy volunteers was associated with significantly increased plasma concentration and elimination half-life of ebastine and carebastine. With ketoconazole the Cmax and AUC were 15 times and 40 times respectively increased, with erythromycin the values were doubled. Both ebastine and carebastine are highly protein bound, >95%. In elderly subjects, no statistically significant changes were observed in the pharmacokinetics compared to those of young adult volunteers. In patients with renal insufficiency the elimination half-life of carebastine was increased to 23-26 hours. Similarly, in patients with hepatic insufficiency, the half-life increased to 27 hours.
INDICATIONS
Ebastine is indicated for the symptomatic treatment of: Seasonal and perennial allergic rhinitis Idiopathic chronic urticaria
CONTRA-INDICATIONS
Patients with a known hypersensitivity to ebastine or any of its ingredients. The safety of ebastine during pregnancy and lactation has not been established. The safety and efficacy of ebastine tablets in children less than 12 years has not been established.
Interactions
The interaction of ebastine in combination with either ketoconazole or erythromycin (both known to prolong the QTc interval) has been evaluated. A significant pharmacokinetic and pharmacodynamic interaction has been observed with these combination; an 18-19 msec (4,7% - 5%) increase in QTc has been reported with either combination. Ebastine does not interact with the kinetics of theophylline, warfarin, cimetidine, diazepam or alcohol. The sedation effect of alcohol and diazepam may be enhanced. When ebastine is administered with food, there is a 1,5 to 2,0 fold increase in the plasma levels and the AUC of the main active acid metabolite of ebastine. This increase does not alter the Tmax. The administration of ebastine with food does not cause a modification in its clinical effect. Ebastine lacks significant sedative effects. Patients should, however, be warned that a small number of individuals may experience sedation. It is therefore advisable to determine individual response before driving or performing complicated tasks. This effect may be compounded by the simultaneous intake of alcohol or other central nervous system depressants.
DOSAGE AND DIRECTIONS FOR USE
Allergic rhinitis 10 mg (one tablet) once a day Idiopathic chronic urticaria 10 mg (one tablet) once a day. Ebastine may be taken with or without food.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS
The most common side-effects are headache, dry mouth and drowsiness. Other less commonly reported side effects include pharyngitis, abdominal pain, dyspepsia, asthenia, epistaxis, rhinitis, sinusitis, nausea and insomnia.

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COMPOSITION
methylprednisolone tablets, USP
PHARMACOLOGICAL CLASSIFICATION
Antihistamines
PHARMACOLOGICAL ACTION
MEpred Tablets contain methylprednisolone which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Methylprednisolone occurs as a white to practically white, odorless, crystalline powder. It is sparingly soluble in alcohol, in dioxane, and in methanol, slightly soluble in acetone, and in chloroform, and very slightly soluble in ether. It is practically insoluble in water. The chemical name for methylprednisolone is pregna - 1,4 - diene - 3,20-dione, 11, 17, 21-trihydroxy-6-methyl-, (6α, 11β)-and the molecular weight is 374.48. The structural for-mula is represented below: Each MEPRED Tablet for oral administration contains , 4 mg, 8 mg, 16 mg of methylprednisolone. Inactive ingredients:
INDICATIONS
Ebastine is indicated for the symptomatic treatment of: Seasonal and perennial allergic rhinitis Idiopathic chronic urticaria
CONTRA-INDICATIONS
Patients with a known hypersensitivity to ebastine or any of its ingredients. The safety of ebastine during pregnancy and lactation has not been established. The safety and efficacy of ebastine tablets in children less than 12 years has not been established.
Interactions
The interaction of ebastine in combination with either ketoconazole or erythromycin (both known to prolong the QTc interval) has been evaluated. A significant pharmacokinetic and pharmacodynamic interaction has been observed with these combination; an 18-19 msec (4,7% - 5%) increase in QTc has been reported with either combination. Ebastine does not interact with the kinetics of theophylline, warfarin, cimetidine, diazepam or alcohol. The sedation effect of alcohol and diazepam may be enhanced. When ebastine is administered with food, there is a 1,5 to 2,0 fold increase in the plasma levels and the AUC of the main active acid metabolite of ebastine. This increase does not alter the Tmax. The administration of ebastine with food does not cause a modification in its clinical effect. Ebastine lacks significant sedative effects. Patients should, however, be warned that a small number of individuals may experience sedation. It is therefore advisable to determine individual response before driving or performing complicated tasks. This effect may be compounded by the simultaneous intake of alcohol or other central nervous system depressants.
DOSAGE AND DIRECTIONS FOR USE
Allergic rhinitis 10 mg (one tablet) once a day Idiopathic chronic urticaria 10 mg (one tablet) once a day. Ebastine may be taken with or without food.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS
The most common side-effects are headache, dry mouth and drowsiness. Other less commonly reported side effects include pharyngitis, abdominal pain, dyspepsia, asthenia, epistaxis, rhinitis, sinusitis, nausea and insomnia.

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COMPOSITION
Levocetirizine dihydrochloride 5 Mg Tablet
Mode of Action
This medicine contains the active ingredient levocetirizine dihydrochloride, which is a type of medicine called a non-sedating antihistamine. Levocetirizine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hayfever. Levocetirizine can also be used to relieve the symptoms of a condition called chronic idiopathic urticaria.
INDICATIONS
Allergic diseases Hayfever Hayfever that occurs throughout the year due to allergies, eg pets, dust mites Ongoing itchy rash with no known cause
Not to be used in
Allergy to medicines that contain piperazine derivatives (your doctor will know more about this - tell them if you are allergic to any medicines) Hereditary galactose intolerance Hereditary Lapp lactase deficiency Inherited inability to absorb the sugars glucose and galactose (glucose-galactose malabsorption) Severely decreased kidney function
Pregnancy and Breastfeeding
The safety of this medicine in pregnancy has not been established. It should therefore be used with caution during pregnancy, and only if the benefits to the mother outweigh any risks to the foetus. Seek medical advice from your doctor. his medicine passes into breast milk. It should be used with caution by breastfeeding mothers, and only if the expected benefit to the mother is greater than the possible risk to the nursing infant. Seek medical advice from your doctor.
SIDE EFFECTS
The most common side-effects are Headache, Abdominal pain, Dry mouth,Fatigue, pharyngitis, Sleepiness, Weakness, rhinitis or Migraine.

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COMPOSITION

Contains Torsemide 10

COMPOSITION

Contains Torsemide 20